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Intranasal mrna vaccine

A Yale School of Medicine research team led by Akiko Iwasaki, PhD, recently found that local vaccines administered with a nasal spray were more effective in protecting mice against influenza than vaccines that are injected into the muscle, the way standard flu shots are done.Iwasaki, who is Waldemar Von Zedtwitz Professor of Immunobiology and professor of molecular, cellular, and developmental.

An intranasal vaccine is a promising option because it closely matches the normal route of infection, self-administration is easy, and it could gain a fair market share in future years. 7. .

To evaluate the impact of mRNA-1273 vaccine dose on protection, animals were challenged 4 weeks after boost with a total dose of 8 × 10 5 plaque-forming units (PFU) of a highly pathogenic stock of SARS-CoV-2 (USA-WA1/2020) by combined intranasal and intratracheal routes for upper and lower airway infection, respectively (fig. S1C).

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. A nasal spray of the Oxford/AstraZeneca COVID-19 vaccine protected hamsters and monkeys against serious disease and reduced the amount of virus in the nose. Less virus in the nasal passages could decrease the risk that vaccinated people spread the virus, even if they don’t feel sick. A clinical trial is underway to test intranasal vaccination.

A variety of mRNA cancer vaccine formats have been developed using common delivery routes (intradermal, intramuscular, subcutaneous or intranasal) and some.

An intranasally administered mRNA vaccine isn't likely to emerge soon, Krammer said, suggesting it might be a "next, next, next-gen vaccine." Several intranasal vaccines are in development.

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